Department of Biology
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Maurice G. Kleve
Associate Professor
Biology and Applied Science
(joint appointment)
(501) 569-3510
(501) 569-3271 (fax)
mgkleve@ualr.edu
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Ph.D. (Developmental-Cell Biology) 1977 University of Houston
M.S. (Endocrinology-Cytology) 1972 Mankato State College, Minn.
B.S. (Biology-Chemistry) 1969 Mankato State College, Minn.
Research Interests
My long-term general research interests are in the areas of cell regulation,
cell recognition, cell-cell surface interactions, cell motility and cytoskeletal
phenomena. My early research focused around the cellular mechanisms of gamete
interaction and early development. I used cell biological and biochemical techniques
to investigate the role of contractile proteins and the cytoskeleton in the process
of fertilization.
In the late 1980's, I began using molecular biological methods in addition to
cellular and biochemical techniques in a variety of research activities including;
the development and application of a high pressure helium flow, particle bombardment
gene gun for the genetic engineering of higher plants; the construction of
recombinant DNA hybrid bacterial toxin genes for use as targeted chemother-apeutic
drugs; and the role of DNA heavy metal adducts in plant and animal cytotoxicity.
Most recently my research interests have focused in two areas, 1) the isolation
and sequence characterization of mitochondrial DNA from avian (hummingbird related)
and nematode (aquatic mermithids) species, and the establishment of systematic,
phylogenetic and geo-ecological relationships among these species based on mtDNA
sequence data, 2) The adoption of the Dictyostelium discoideum as a research system
for the analysis of the role and function of developmental genes. The first genes
being studied by this system are small GTPase switches of the Ras gene family.
My interest in Ras-like genes focuses on their role in cell differentiation. These
proteins are involved in a wide range of processes which include activities such
as signal transduction, regulation of the cytoskeleton, and vesicle transport pathways.
This new research activity brings me full circle to my early interests in cell-cell
communication and the involvement of the cytoskeleton in developmental phenomena.
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Courses Taught
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BIOL 1401 General Biology
BIOL 3400 Developmental Biology
BIOL 4414 Biological Methods and Instrumentation
BIOL 4416/5416 Microscopy
BIOL 4418/5418 Biotechnology
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Appointments
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Sea Grant Research Fellow, National Oceanic and Atmospheric Administration, National Marine Fisheries Service, Department of Biology, Marine Station, University of Houston, Galveston, Texas. (1975-1977)
Research Biologist in Reproductive Physiology, National Oceanic and Atmospheric Administration, National Marine Fisheries Service, Galveston, Texas. (1977-1978)
Postdoctoral Scholar, Department of Animal Science, University of California, Davis, California. (1978-1980)
Assistant Professor, Department of Biology, University of Arkansas at Little Rock, Little Rock, Arkansas. (1980-1986)
Associate Professor, Department of Biology, University of Arkansas at Little Rock, Little Rock, Arkansas. (1986-present)
Visiting Associate Professor, Department of Molecular Biology, University of Texas at Dallas, Dallas, Texas. (1989-1990)
Director, Altheimer Microscopy Laboratory, Department of Biology, University of Arkansas at Little Rock, Little Rock, Arkansas. (1990-present)
Director, Arkansas Rice Biotechnology Project, Department of Biology, University of Arkansas at Little Rock, Little Rock, Arkansas and the USDA-ARS, Stuttgart, AR. (1990-1996)
Director, Molecular Biotechnology Undergraduate Degree Program, Department of Biology, University of Arkansas at Little Rock, Little Rock, Arkansas. (1997-present)
Associate Professor, Joint Appointment in Department of Applied Science, College of Information Science and Systems Engineering, and the Biology Department, College of Science and Mathematics, University of Arkansas at Little Rock, Little Rock, Arkansas. (1999)
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Selected Publications
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Johnson, A.A. and M.G. Kleve. 1999. Strelkovimermis amphidis n. sp from chironomid adults emerging from Lake Itasca and Long Lake, Minnesota. J. Parasitol. (In Press).
Johnson, A.A. and M.G. Kleve. 1999. Hydromermis contorta (Kohn) and Hydromermis pseudocontorta n. sp. from chirononmids of Lake Itasca and Long Lake, Minnesota. Journal of Parasitol. (In Press).
Johnson, A.A. and M.G. Kleve. 1998. Strelkovimermis arkansensis N. sp and Hydromermis welchi N. sp. from Chirononmid imagos. Journal of Parasitol. 84(1):135-139.
Evans, R.P., C.L. Nelson, M.G. Kleve and S.G. Hickman. 1998. Visualization of the natural morphology of bacterial glycocalyx in wounds by scanning electron microscopy of acute surgical osteomyelitis. Clin. Orthop. 347:243-249.
Buczynski, G., B. Grove, J. Bush, M.G. Kleve, R.A. Firtel and J. Cardelli. 1997. Inactivation of two Dictyostelium discoideum genes, DdPIK1 and DdPIK2, encoding proteins related to mammalian phosphatidylinositide 3-kinase, results in defects in endocytosis, lysosome to post-lysosome transport and actin cytoskeleton organization. J. Cell Biol. 136:1271-1286.
Johnson. A.A. and M.G. Kleve. 1997. Two new species of imagocidal Hydromermis (Nematoda: Mermithidae) form Endochironomus subtendens (Townes) (Diptera: Chironimidae) from Lake Itasca, Minnesota, U.S.A. J. Parasitol. 83(1):131-136.
Johnson. A.A. and M.G. Kleve. 1996. Strelkovimermis acuticauda n. sp. and Strelkovimermis buccalis n. sp. (Nematoda: Mermithidae) from adult chironimids (Dipotera:Chironomidae) from Lake Itasca, Minnesota. J. Parasitol. 82(3):478-483.
Johnson. A.A. and M. G. Kleve. 1995. Abathymersis fiseri n. sp. and Abathymermis shocki n. sp. (Nematoda: Mermithidae) from midge (Dipera: chironomidae) Imagos emerging from Lake Itasca, Minnesota, U.S.A. Invertebrate Biology. 114(1): 19-26.
Lindquist, D.A., M.K. Mazumder, K.B. Tennal, M.H. McKendree, M.G. Kleve and S. Scruggs. 1995. Electrostatic beneficiation of coal. Proc. Mat. Res. Soc. 371:459-463.
Lindquist, D.A., A.D. Wilson, A.L. Smoot, K.B. Babb and M.G. Kleve. 1995. Supported membranes of aluminum phosphate on porous alumina substrates. Proc. Mat. Res. Soc. 371:345-351.
Babb, K.B., D.A. Lindquist, S.S. Rooke, W.E. Young and M.G. Kleve. 1995. Porous solids of boron phosphate, aluminum phosphate, and silicon phosphate. Proc. Mat. Res. Soc. 371:211-215.
Johnson, A.A. and M. G. Kleve. 1994. Lanceimermis minnesotensis n. sp. and Gastromermis microspicularis n. sp. (Nematoda: Mermithidae), from adult chironomids emerging from Lake Itasca, Minnesota, U.S.A. Trans. Am. Microsc. Soc. 113(2): 117-189. 1994.
Johnson, A.A. and M.G. Kleve. 1993. Two new Species of Strelkovimermis (Nematoda: Mermithidae) as Imagicidal Parasites of Chironomids (Diptera: Chironomidae) in Lake Itasca, Minnesota, U.S.A. Trans. Am. Micros. Soc. 112(2):128-139.
Johnson, A.A. and M.G. Kleve. 1993. Trophomermis itascensis n. gen., n. sp. (Nematoda: Mermithidae), an Imagicidal Parasite of Chironomids in Lake Itasca, Minnesota, U.S.A. Trans. Am. Micros. Soc. 112(2):121-127.
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Seminars
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Baltosser, W.H., J.M. Bush, M.G. Kleve, and S.M. Post. 1998. Molecular systematics of hummingbirds occuring in North Mexico, United States and Canada. North American Ornithological Conference, April, 1998., St. Louis, Mo.
Lanza, J.M, D. Warrinerm, M.G. Kleve, and M. McHenry. 1997. The physiological effects of nectar-born amino acids on cabbage white Butterflies, Pieris rapae. Entomological Society of America Annual Meeting. Invited Symposium presentation: Dec. 1997.
Ricks, E.J. and M.G. Kleve. 1997. Protocols for analysis of the Mitochondrial Genome of the Nematode Turbatrix aceti. Proceedings of the Fourth Annual Arkansas Undergraduate Research Conference. Henderson State University.
Waldrens, C. and M.G. Kleve. 1997. Phylogenetic analysis of avian mtDNA from hummingbirds and swifts. Fourth Annual McNair Scholars Research Symposium. Little Rock, Arkansas.
Ricks, E.J. and M.G. Kleve. 1996. Preliminary analysis of soybean mature caryopsis callus and cell suspension culture: Response to various plant growth regulator concentrations. National McNair Scholars Research Symposium, Knoxvill, TN.
Ricks, E.J. and M.G. Kleve. 1996. Analysis of the mitochondrial genome of the free living nematode, Turbatrix aceti. Third Annual McNair Scholars Research Symposium, Little Rock, Arkansas.
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Current Grant Activity
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Nucleotide sequence of putative Rho-GDI genes in Dictyostelium discoideum. FSAP (UALR) 5/98 - 4/00, $4000.00
Howard Hughes Medical Institute Undergraduate Education Grant at UALR Biology. Howard Hughes Medical Institute. Pending, $1.7 million.
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